乳幼児の急性化膿性中耳炎入院例の臨床的・免疫学的検討(<特集>小児科学教室大澤真木子教授開講5周年記念)

概要

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We surveyed 35 patients who had been diagnosed with acute purulent otitis media (AOM) who were admitted to our department between 1995 and 1998. Penicillin-resistant Streptcoccus peumoniae (PRSP) was isolated from 15 patients (42%). The efficacy of cefotaxim (CTX) was satisfactory in all cases in which it was used. However, 4 patients in whom cefotium (CTM) was used showed no improvement, and 2 had recurrence of AOM. Ten of 15 patients who suffered from PRSP underwent immunologic examinations. The IgG2 level of one case was reduced; this patient also had MRSA infection. Levels of serum IgG2 antibody specific for S. peumoniae were low in 2 patients, one of whom had recurrent AOM, and the other had complications of mastoiditis. A decrease in plasma IgG2 levels might predict recurrent or severe AOM. Immunological studies with reagents such as specific antibody for S. peumoniae might be useful for prognostic estimation of AOM.
東京女子医科大学の論文
2000-06-25