Successful Treatment with Entecavir for Reactivation of Hepatitis B Virus Following Systemic Chemotherapy in a Hepatitis B Surface Antigen-negative Patient with Colorectal Cancer
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概要
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Reactivation of hepatitis B virus (HBV) has recently been reported as a fatal complication in patients undergoing cytotoxic chemotherapy. We herein describe a case of reactivation in a 76-year-old man who had undergone pelvic exenteration for colorectal cancer (CRC). He was treated with a modified FOLFOX6 chemotherapy regimen after the operation. Thirteen months later, his laboratory data showed severe liver dysfunction. His hepatitis B surface antigen (HBsAg) test was positive, and his HBV-DNA level was elevated. We diagnosed the patient with HBV reactivation as his HBsAg test was negative before starting chemotherapy. His liver dysfunction improved after administration of entecavir. This is the first report describing HBV reactivation following chemotherapy for an HBsAg-negative CRC patient.
著者
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Iyama Satoshi
Department Of Gastroenterology Sapporo National Hospital
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TAKIMOTO RISHU
Department of Internal Medicine, Naganuma Municipal Hospital
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Hayashi Tsuyoshi
Department Of 4th Internal Medicine Sapporo Medical University School Of Medicine
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Kato Junji
Department Of Applied Chemistry Waseda University
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Hisai Hiroyuki
Department Of Gastroenterology Date Red Cross Hospital
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Kawano Yutaka
Department Of Pediatrics Kitasato University School Of Medicine
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Sato Yasushi
Department Of Agricultural Chemistry Meijo University
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MIYANISHI Koji
Department of Internal Medicine IV, Sapporo Medical University Hospital, Sapporo Medical University
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Sato Tsutomu
Departmenet of Physics,Faculty of Sience,Hirosaki University
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Takada Kohichi
Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Japan
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Kato Junji
Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Japan
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Okagawa Yutaka
Department of Internal Medicine and Gastroenterology, Date Red Cross Hospital, Japan
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Koshiba Yutaka
Department of Internal Medicine and Gastroenterology, Date Red Cross Hospital, Japan
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Wada Hironori
Department of Internal Medicine and Gastroenterology, Date Red Cross Hospital, Japan
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Miyazaki Etsu
Department of Internal Medicine and Gastroenterology, Date Red Cross Hospital, Japan
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Kanari Yusuke
Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Japan
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Kobune Masayoshi
Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Japan
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Hisai Hiroyuki
Department of Internal Medicine and Gastroenterology, Date Red Cross Hospital, Japan
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Kawano Yutaka
Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Japan
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