免疫グロブリン定量値と血清蛋白分画値に乖離がみられた２症例

概要

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Two cases with abnormal laboratory data due to the presence of monoclonal proteins belonging to minor subclasses are described.Case 1 was a patient with IgA-κ type M-protein. The monoclonal IgA value as determined by serum protein electrophoresis was 6,450 mg / dl, while the serum IgA concentration was 4,310 mg / dl by turbidimetric immunoassay. Immunoelectrophoresis of the patient serum showed double IgA precipitate lines. We identified that the M-protein in this patient as the IgA2m(1) allotype by immunofixation electrophoresis using anti-IgA subclass antisera and SDS-PAGE without 2-mercaptoethanol.Case 2 was a patient with IgG-κ type M-protein. The monoclonal IgG was found to have mobility to α2 region. The γ-globulin fraction in this patient as determined by serum protein electrophoresis was 630 mg / dl, while the serum IgG concentration was 1,370 mg / dl by turbidimetric immunoassay. Immunofixation electrophoresis using anti-IgG subclass antisera revealed that this M-protein was the IgG4-κ type.In both cases, M-proteins belonging to minor subclasses may cause abnormal reactions in immunochemical determination.
日本電気泳動学会の論文