CSF Uric Acid Levels in Patients with Brain Tumor:-Diagnostic Value compared with CSF Lactate Dehydrogenase Activities-

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Uric acid is the end-product of purine metabolism, and the purines are nitrogenous bases derived from the breakdown of nucleic acids. It was presented by the authors at the Eighteenth Annual Meeting of the Japanese Society of Neurology in Nagoya, May 18,1977, that CSF uric acid levels were increased in patients with histologically malignant brain tumor. Responsible factors for increased CSF uric acid levels are thought to be (1) increased permeability of blood-CSF barrier; (2) cerebral cell necrosis; and (3) increased turnover of the nucleic acid. The purpose of this paper is to find out the diagnostic value of CSF uric acid levels in patients with brain tumor compared with CSF lactate dehydrogenase activities. CSF uric acid levels and lactate dehydrogenase activities were investigated in 30 cases of normal control and in 52 cases of brain tumor. The mean values and standard deviations of CSF uric acid levels and lactate dehydrogenase activities were as follows in normal controls.Increased CSF uric acid levels and lactate dehydrogenase activities over the age of 50 are thought to be due to cerebral cell necrosis. Both CSF uric acid levels and lactate dehydrogenase activities were increased in histologically malignant brain tumors with numerous mitotic figures such as grade III-IV astrocytoma, medulloblastoma and sarcomatous meningioma. But, there is a strange phenomenon named "paradoxical normalization". It is a phenomenon that both CSF uric acid levels and lactate dehydrogenase activities are normalized in histologically malignant brain tumors with cyst formation. CSF uric acid levels were not influenced by increased intracranial pressure. But CSF lactate dehydrogenase activities were more easily influenced and increased in almost all cases above 400 mm H<SUB>2</SUB>O, even if these cases were histologically benign. Uric acid levels and lactate dehydrogenase activities were investigated in the cyst fluids of brain tumor. Both of them were more concentrated in the cyst fluid than in the CSF. In the malignant brain tumor, uric acid levels and lactate dehydrogenase activities in the cyst fluids were higher than the serum levels. But in the benign brain tumor, they were lower than the serum levels.
Japanese Society of Gout and Nucleic Acid Metabolismの論文

CSF Uric Acid Levels in Patients with Brain Tumor:-Diagnostic Value compared with CSF Lactate Dehydrogenase Activities-

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