Serum and Urinary Uric Acid in primary Hyperparathyroidism

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Pre and postoperative values of serum uric acid and 24 hr urinary excretion of uric acid were measured in 29 patients with primary hyperparathyroidism. Serum uric acid levels were 6.0 ± 1.0 mg/dl and 6.0 ± 0.6 mg/dl in males, and 5.7 ± 0.8 mg/dl and 5.3 ± 0.1 mg/dl in females, respectively pre and postoperatively. No significant change was observed. Positive correlation (p<0.01) was found between the ratios of Ca/Creatinine and Uric Acid/Creatinine before but not after operation. Serum uric acid levels increased on first to third days after operation and returned normal within a week. Under low calcium diet for five days, serum uric acid levels were elevated. These findings suggest that primary hyperparathyroidism has some influences on uric acid metabolism.
Japanese Society of Gout and Nucleic Acid Metabolismの論文