Two Cases of Everolimus-associated Interstitial Pneumonia in Patients with Renal Cell Carcinoma
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概要
- 論文の詳細を見る
We herein report two cases of everolimus-associated interstitial pneumonia in patients with renal cell carcinoma. A 68-year-old Japanese man (case 1) was admitted to our hospital because of progressive dyspnea, left infiltration and consolidation on chest radiographs. He had started receiving everolimus (10 mg daily) three months before the admission for the treatment of recurrent renal cell carcinoma. Bronchoalveolar lavage fluid taken from his left B4 showed a marked increase of lymphocytes (42.9%). An organizing pneumonia pattern of everolimus-associated interstitial pneumonia was strongly suspected radiologically, and treatment with high-dose corticosteroids, discontinuation of everolimus and oxygen support was started. The treatment was successful, and the patient recovered with only minor pulmonary fibrotic changes in the left lower lobe. A 57-year-old Japanese man (case 2) was referred to our department for the evaluation of interstitial pneumonia. He had started to receive everolimus (10 mg daily) four months previously. Chest CT demonstrated interstitial pneumonia predominantly in bilateral lower lobes, with small pulmonary metastatic nodules. His pulmonary complications were spontaneously resolved eight days after the discontinuation of everolimus. To the best of our knowledge, Case 1 is the first reported case of successfully treated organizing pneumonia pattern of interstitial pneumonia with acute respiratory failure induced by everolimus in Japan.
- 社団法人 日本内科学会の論文
著者
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Mukae Hiroshi
Department of Anesthesia, Emergency and Critical Care Medical Center, Kitakyushu Municipal Yahata Ho
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Ishimoto Hiroshi
Department of Anesthesia, Emergency and Critical Care Medical Center, Kitakyushu Municipal Yahata Ho
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Yatera Kazuhiro
Department Of Respiratory Disease University Of Occupational And Environ Mental Health
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Matsumoto Tetsuro
Department Of University Of Occupational And Environmental Health
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Kawanami Toshinori
Department Of Respiratory Medicine School Of Medicine University Of Occupational And Environmental H
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Nagata Shuya
Department Of Respiratory Medicine School Of Medicine University Of Occupational And Environmental H
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Nishida Chinatsu
Department Of Respiratory Medicine School Of Medicine University Of Occupational And Environmental H
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Yamasaki Kei
Department Of Respiratory Medicine School Of Medicine University Of Occupational And Environmental H
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Yoshida Takeshi
Department of Urology, University of Occupational and Environmental Health, Japan
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Yoshida Takeshi
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
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Akata Kentarou
Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan
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Kozaki Minako
Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan
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Matsumoto Tetsuro
Department of Urology, University of Occupational and Environmental Health, Japan
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