Welder's Pneumoconiosis : Diagnostic Usefulness of High-resolution Computed Tomography and Ferritin Determinations in Bronchoalveolar Lavage Fluid
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概要
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Objective We assessed the usefulness of high-resolution computed tomography (HRCT) and ferritin determinations in bronchoalveolar lavage (BAL) fluid for diagnosis of welders pneumoconiosis. Patients and Methods We investigated 11 patients with welders pneumoconiosis who were 34 to 67 years old and had been welding for 17 to 45 years. Ten patients were current smokers. We performed chest radiography and HRCT, and measured serum ferritin on all 11 patients. We obtained BAL fluid in 9 cases and transbronchial lung biopsy (TBLB) specimens in 7. Ferritin concentrations in BAL fluid were compared with those in welders without pneumoconiosis and other pneumoconiosis cases. Results HRCT revealed small centrilobular nodules in 9 cases, mild fibrotic changes in 3, and emphysematous changes in 3. Serum ferritin concentrations were elevated (>240 ng/ml) in 10 cases. Ferritin concentrations in BAL fluid were higher in welders pneumoconiosis than in the occupational control group. Conclusion In welders pneumoconiosis, small centrilobular nodules are frequently seen on HRCT, and ferritin shows elevations in serum and/or BAL fluid. Such ferritin determinations are of value in diagnosis.(Internal Medicine 41: 1111-1117, 2002)
- 社団法人 日本内科学会の論文
- 2002-12-01
著者
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Ito Toshiro
Department of Thoracic and Cardiovascular Surgery, Hakodate Goryoukaku Hospital
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YATERA Kazuhiro
Department of Respiratory Diseases
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Ito Toshiro
Department Of Respiratory Disease University Of Occupational And Environmental Health
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Ito Toshiro
Department Of Botany Faculty Of Science Kyoto University:department Of Biophysics Faculty Of Science
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Kido Masamitsu
Department Of Respiratory Disease University Of Occupational And Environ Mental Health
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YOSHII Chiharu
Department of Respiratory Disease, University of Occupational and Environmental Health
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MATSUYAMA Tsuneo
Kyushu Medical Institute for Occupational Health
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TAKAZAWA Akiko
First Department of Internal Medicine, University of Occupational and Environmental Health
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HAYASHI Toshinari
Department of Respiratory Disease, University of Occupational and Environ mental Health
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IMANAGA Tomotoshi
Department of Respiratory Disease, University of Occupational and Environ mental Health
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Yoshii Chiharu
Department Of Respiratory Disease University Of Occupational And Environmental Health
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Takazawa Akiko
First Department Of Internal Medicine University Of Occupational And Environmental Health
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Takazawa Akiko
First Department Of Internal Medicine School Of Medicine University Of Occupational And Environmenta
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Yatera Kazuhiro
Department Of Respiratory Disease University Of Occupational And Environ Mental Health
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Hayashi Toshinari
Department Of Respiratory Disease University Of Occupational And Environ Mental Health
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Imanaga Tomotoshi
Department Of Respiratory Disease University Of Occupational And Environ Mental Health
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