Akinetic Mutism Caused by HIV-associated Progressive Multifocal Leukoencephalopathy was Successfully Treated with Mefloquine: A Serial Multimodal MRI Study
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概要
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We report a case of a patient with highly active anti-retroviral therapy-resistant human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML). The patient showed an improvement in imaging findings and clinical symptoms after mefloquine was introduced as an additional treatment. Serial assessment of white matter lesions was conducted by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted imaging (DWI). As the clinical symptoms improved, the N-acetylaspartate/creatine ratio increased, the choline/creatine ratio decreased, and the elevated ADC value decreased. These concomitant changes suggested that 1H-MRS and DWI were useful for the assessment of the therapeutic effect on PML.
著者
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Ueno Hiroki
Department Of Clinical Neuroscience And Therapeutics Hiroshima University
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Ohshita Tomohiko
Department Of Clinical Neuroscience And Therapeutics Hiroshima University Graduate School Of Biomedi
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Nakamura Takeshi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Yamawaki Takemori
Department Of Clinical Neuroscience And Therapeutics Hiroshima University Graduate School Of Biomedical Sciences
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Matsumoto Masayasu
Department of Clinical Neuroscience and Therapeutics Division of Integrated Medical Science, Graduate School of Biomedical Sciences, Hiroshima University
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Nakamura Takeshi
Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
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Sekine Mayu
Department of Neurology, Tokyo Saiseikai Central Hospital, Japan
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Naito Kasane
Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
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Kanemitsu Munekazu
Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
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Ohshita Tomohiko
Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
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Ohshita Tomohiko
Departmant of Clinical Neuroscience and Therapeutics, Hiroshima University
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Sekine Mayu
Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
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