Management and Two-Year Long-Term Clinical Outcome of Acute Coronary Syndrome in Japan:– Prevention of AtherothrombotiC Incidents Following Ischemic Coronary Attack (PACIFIC) Registry –
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概要
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Background: Japanese patients have been at low risk for cardiovascular events compared with Western countries, but the data regarding current treatment status and rate of subsequent atherothrombotic events after acute coronary syndrome (ACS) are limited in Japanese patients. The objective of this study was to clarify the treatment status and long-term outcomes in Japanese ACS patients. Methods and Results: The Prevention of AtherothrombotiC Incidents Following Ischemic Coronary attack (PACIFIC) registry is a multicenter, prospective observational study of Japanese ACS patients. Consecutive patients aged ≥20 years hospitalized for ACS were enrolled from 96 hospitals and followed up for 2 years (n=3,597). ST-segment elevation myocardial infarction (STEMI) was the most frequent type of ACS (59.4%). The vast majority (93.5%) of patients underwent percutaneous coronary intervention (PCI), with a success rate of 93.9%. Frequent use of guideline-recommended pharmacological treatments was also indicated. Cumulative incidence of major adverse cardiac and cerebrovascular events (MACCE) was 6.4% (7.5% for STEMI and 4.8% for non-STEMI or unstable angina), and all-cause mortality was 6.3%. Conclusions: The PACIFIC registry has identified an incidence of MACCE of 6.4% and that of mortality at 6.3% in Japanese ACS patients at 2-year follow-up. A high proportion of patients underwent PCI, and the PCI success rate was high. Proactively performed successful PCI was considered to have contributed to favorable outcomes in these patients. (Circ J 2013; 77: 934–943)
著者
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Tsukahara Kengo
Division Of Cardiology Yokohama City University Medical Center
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Kitakaze Masafumi
Cardiovascular Div. Of Medicine National Cardiovascular Center
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Miyauchi Katsumi
Department Of Cardiology Juntendo University School Of Medicine
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Ogawa Hisao
National Cardiovascular Center Hospital Cardiac Division
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Matsubara Tetsuo
Toyohashi heart center
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Kimura Kazuo
Division Of Cardiology Yokohama City University Medical Center
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Daida Hiroyuki
Department Of Cardiology
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Morino Yoshihiro
Division Of Cardiology Department Of Internal Medicine Tokai University School Of Medicine
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Origasa Hideki
Division Of Biostatistics And Clinical Epidemiology University Of Toyama Graduate School Of Medicine
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Ikari Yuji
Department Of Cardiology Tokai Univeristy
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Yokoi Hiroyoshi
Department Of Cardiac Rehabilitation Kokura Memorial Hospital
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Isshiki Takaaki
Division Of Cardiology Department Of Internal Medicine Teikyo University School Of Medicine
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KITAKAZE Masafumi
Cardiovascular Division, National Cerebral and Cardiovascular Center
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Kimura Takeshi
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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KIMURA Takeshi
Department of Applied Chemistry and Molecular Science, Faculty of Engineering, Iwate University
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Miyauchi Katsumi
Department of Cardiology, Juntendo University Graduate School of Medicine
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Ogawa Hisao
National Cerebral and Cardiovascular Center
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TSUTSUI Hiroyuki
Department of Cardiology, Iizuka Hospital
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Matsumoto Masayasu
Department of Clinical Neuroscience and Therapeutics Division of Integrated Medical Science, Graduate School of Biomedical Sciences, Hiroshima University
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Kobayashi Masayuki
Medical Operations, Sanofi K.K.
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Daida Hiroyuki
Department of Cardiology, Juntendo University Graduate School of Medicine
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