Long-term Sequential Changes of Radiation Proctitis and Angiopathy in Rats

スポンサーリンク

概要

• 論文の詳細を見る

• The purpose of the present study was to establish an experimental rat model for late radiation proctitis, and to examine the assessment strategy for late radiation proctitis. A total of 57 Wistar rats were used. Fourty-five of the rats were exposed to selective rectal irradiation with a single fraction of 25 Gy. These rats were sacrificed at the 4th, 12th, 24th, and 37th week following irradiation. The remaining 12 rats comprised the control group without irradiation. The rectal mucosa of each rat was evaluated macroscopically and pathologically. The number of vessels in the rectal mucosa was counted microscopically. In addition, the vascular stenosis was evaluated. In the results, the degree of clinical and macroscopic findings decreased following acute proctitis and developed later. In the pathological examination, mucosal changes and microangiopathy were followed up, as well. The absolute number of vessels in the rectum was the greatest at the 12th week following irradiation and was the lowest in the control group. The severity of the microangiopathy was also well evaluated. To conclude, we established an animal experimental model of late radiation proctitis, and also established an assessment strategy to evaluate objectively the severity of late radiation proctitis with focusing on microangiopathy using an animal experimental model. This model can be used as an animal experimental model of radiation-induced microangiopathy.

• Journal of Radiation Research 編集委員会の論文

著者

• Kamikonya Norihiko

  Department Of Radiology Hyogo College Of Medicine

• Kimura Takeshi

  Department Of Cardiology Kobe City Medical Center General Hospital

• Hirota Shozo

  Department Of Radiology Hyogo College Of Medicine

• Tsujimura Tohru

  Department Of Pathology Hyogo College Of Medicine

• Shikata Toshiyuki

  Department Of Macromolecular Science Osaka University

• Doi Hiroshi

  Department Of Agricultural Chemistry Kyoto Prefectural University

• Fujiwara Masayuki

  Department Of Applied Physics Osaka University:(present Address) Asada Fundamental Research Laborato

• Nakamura Takeshi

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University

• Inoue Hiroyuki

  Department Of Gastroenterology Aichi Cancer Center Hospital

• Takada Yasuhiro

  Department Of Biological Sciences Faculty Of Science Hokkaido University

• INOUE Hiroyuki

  Department of Radiology, Hyogo College of Medicine

• SHIKATA Toshiyuki

  Department of Pharmacy, The Hospital of Hyogo College of Medicine

• DOI Hiroshi

  Department of Radiology, Hyogo College of Medicine

• TSUBOI Keita

  Department of Radiology, Hyogo College of Medicine

• MIURA Hideharu

  Department of Radiology, Hyogo College of Medicine

• TANOOKA Masao

  Department of Radiology, Hyogo College of Medicine

• FUJIWARA Masayuki

  Department of Radiology, Hyogo College of Medicine

• KIMURA Takeshi

  Department of Pharmacy, The Hospital of Hyogo College of Medicine

• KIMURA Takeshi

  Department of Applied Chemistry and Molecular Science, Faculty of Engineering, Iwate University

関連論文

• PJ-814 Assessment of Residual Myocardial Viability in Patients with Prior Myocardial Infarction : Analysis of Intracoronary Flow and Pressure Measurements(PJ137,Intravascular Imagings 1 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of T
• PJ-458 Changing Profile of Infective Endocarditis : Results of 10-year Survey in Our Hospital(PJ077,Infection/Inflammation/Immunity (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-558 Micovascular Dysfunction Immediately after Percutaneous Coronary Intervention is Associated with Sustained Hemodynamic Abnormalities in Repertused Acute Myocardial Infarction(PE094,ACS/AMI (Clinical/Diagnosis) 2 (IHD),Poster Session (English),The 7
• PJ-409 Identification of Clinical Characteristics Favorably Treated with Non-Stent Strategy for Sirolimus-Eluting Stent Restenosis : Insights from J-CYPHER Registry(PJ069,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Poster Session (Japanese
• FRS-114 Predictor of Target Lesion Revascularization and Efficacy of Final Kissing Balloon Technique using One-Stent Technique in Coronary Bifurcation Lesions(FRS23,Clinical Evidence of DES Era (1) (IHD),Featured Research Session (English),The 73rd Annual
• OE-110 The Impact of Preloading and Discontinuation of Dual Antiplatelet Therapy on Stent Thrombosis for ACS Lesion. : Based on j-Cypher Registry(Thromboembolism/Antithrombotic therapy/Thrombolysis(01)(H),Oral Presentation(English),The 72nd Annual Scienti
• Effects of Obstructive Sleep Apnea with Intermittent Hypoxia on Platelet Aggregability
• PJ-577 The Antiplatelet Effect of Aspirin does not Change after 2-year Interval(PJ097,Cardiovascular Pharmacology (Clinical) (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Clopidogrel Resistance in Japanese Patients Scheduled for Percutaneous Coronary Intervention(Ischemic Heart Disease)
• OJ-218 Risk Factors for Recurrent Restenosis of Post-Sirolimus-Eluting Stent Restenosis : Insights From j-CYPHER Registry(Restenosis basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
• OE-001 Clinical Results after Sirolimus-Eluting Stent Implantation for the Chronic Total Occlusion in the j-CYPHER Registry(Coronary revascularization, PCI(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation
• FRS-118 Predictors of Target Lesion Revascularization After Sirolimus-Eluting Stent Implantation for the Lesion with Acute Coronary Syndrome. : Based on j-Cypher Registry(Novel Aspects for Acute Coronary Syndrome(IHD),Featured Research Session,The 72nd An
• PJ-726 A Multicenter Registry of a Novel Filter Device for Distal Protection ; Filtrap ^Registry(Coronary revascularization, PCI-17, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-286 Long-term Follow-up of Catheter Ablation for Chronic Atrial Fibrillation : Differences in Clinical Characteristics between Patients with and without Successful Outcome(PJ048,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 3 (A),Poster Session (Ja
• Impact of CYP2C19 Polymorphisms on the Antiplatelet Effect of Clopidogrel in an Actual Clinical Setting in Japan
• Incidence of and Risk Factors for Contrast-Induced Nephropathy After Cardiac Catheterization in Japanese Patients
• Coronary Risk Factor Profile and Prognostic Factors for Young Japanese Patients Undergoing Coronary Revascularization
• PJ-795 Narrow QRS Duration Predicts Improvement of Left Ventricular Systolic Function by Beta-blockers in Chronic Heart Failure(PJ133,Heart Failure (Treatment) 4 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation
• PJ-710 Efficasy of Catheter Ablation for Atial Fibrillation with Sinus Node Dysfunction(PJ119,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 7 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-571 Multiple Mechanisms underlie Long QT Syndrome by the Change of Amino Acid R259 in the Intracellular S4-S5 Linker of KCNQ1(PJ096,Arrhythmia, Others (Clinical/Pathophysiology) 4 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The
• Aldosterone Signaling Associates With p300/GATA4 Transcriptional Pathway During the Hypertrophic Response of Cardiomyocytes
• MicroRNA-1 and MicroRNA-133 in Spontaneous Myocardial Differentiation of Mouse Embryonic Stem Cells
• PJ-759 Atherosclerotic Change is Shown in In-Stent Restenoisis Lesion : Drug-Eluting Stent versus Bare Metal Stent(PJ127,Intravascular Imagings 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-758 Association of Statin Therapy with Reduced Yellow Plaque Existence of In-Stent Restenosis in Drug-Eluting Stent(PJ127,Intravascular Imagings 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Diabetes Mellitus Is a Major Negative Determinant of Coronary Plaque Regression During Statin Therapy in Patients With Acute Coronary Syndrome : Serial Intravascular Ultrasound Observations From the Japan Assessment of Pitavastatin and Atorvastatin in Acu
• PJ-526 Relationship between Lipoprotein (a) and the Plaque Morphology of the Non-infarcted Vessels in Patients with Acute Myocardial Infarction(PJ089,Atherosclerosis (Clinical/Pathophysiology) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific M
• PJ-149 Clinical Significance of Early Recurrence of Atrial Fibrillation after Left Atrial Ablation in Patients with Permanent Type of Atrial Fibrillation(PJ025,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 2 (A),Poster Session (Japanese),The 73rd Annu
• PJ-033 An Effect of the Statin for the Patients with Chronic Limb Ischemia who Received Endovascular Treatments on Long Term Outcome(PJ006,Lipid Disorders (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
• PE-387 Clinical Features of Early Recurrence and Delayed Cure after Radiofrequency Catheter Ablation of Paroxysmal Atrial Fibrillation(PE065,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) 3 (A),Poster Session (English),The 73rd Annual Scientific
• Changes of Matrix Metalloproteinase-9 Level Is Associated With Left Ventricular Remodeling Following Acute Myocardial Infarction Among Patients Treated With Trandolapril, Valsartan or Both
• Diabetes Mellitus Is a Major Negative Determinant of Coronary Plaque Regression During Statin Therapy in Patients With Acute Coronary Syndrome : Serial Intravascular Ultrasound Observations From the Japan Assessment of Pitavastatin and Atorvastatin in Acu
• IS075 Thrombectomy with AngioJet Catheter in Native Coronary Arteries for Patients with Acute or Recent Myocardial Infarction
• Left Ventricular Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Failing Rat Hearts
• PJ-040 The Impact of Chronic Kidney Disease on Long-term Outcome after Acute Coronary Syndrome, over a 10-Year Follow Up Period(PJ007,Kidney/Renal Circulation/CKD 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
• PE-374 Propensity Analysis of Long-term Outcome (Total-mortality and Acute Coronary Syndrome) of Drug-Eluting Stents versus Bare-Metal Stents(PE063,Coronary Revascularization, PCI (DES) 5 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting o
• PJ-754 Intravascular Ultrasound Analysis of Coronary Atheroma in Patients with and without Chronic Kidney Disease following Statin Therapy from JAPAN-ACS Study(PJ127,Intravascular Imagings 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting
• PE-367 Localized Effects of Lipid-lowering Therapy on the Coronary Artery Plaques : Subanalysis of JAPAN-ACS Study(PE062,Atherosclerosis (Clinical/Treatment) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Soc
• PJ-376 Effect of Waon Therapy on Oxidative Stress in Patients with Chronic Heart Failure(PJ063,Heart Failure (Treatment) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-795 Narrow QRS Duration Predicts Improvement of Left Ventricular Systolic Function by Beta-blockers in Chronic Heart Failure(PJ133,Heart Failure (Treatment) 4 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation
• PJ-707 Amiodarone versus Bepridil for Atrial Fibrillation in Patients with Impaired Left Ventricular Function(PJ119,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 7 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circul
• OE-392 Progranulin Expression in Advanced Human Atherosclerotic Plaque(OE66,Atherosclerosis (Clinical/Pathophysiology) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• A Case Study on Cardiac Imaging in Patients with Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy : A Comparison between 64-Slice Computed Tomography, Magnetic Resonance Imaging and Electroanatomical Mapping
• Characterization of the Antiplatelet Effect of Aspirin at Enrollment and After 2-Year Follow-up in a Real Clinical Setting in Japan
• PJ-340 Curcumin, a Natural p300-specific Histone Acetyltransferase Inhibitor, Possesses Beneficial Effects in addition to ACE Inhibitor after Myocardial Infarction in Rats(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),The 73rd Annual
• PE-528 Cyclin-dependent kinase-9 is Recruited on Cardiac Hypertrophic Response Gene Promoters through GATA4 in Cardiomyocytes(PE089,Cardiomyopathy/Hypertrophy (Basic) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulat
• PE-351 Synergistic Effects of G-CSF and Erythropoietin on Left Ventricular Systolic Function in Heart Failure after Rat Myocardial Infarction(PE059,Heart Failure (Treatment) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese
• 2 Prognosis of Japanese Patients after Coronary Revascularization : Perspectives from CREDO-Kyoto Registry(Therapeutic Decision Making for Coronary Artery Disease Among PCI, CABG, and Medication,Symposium 3 (SY-03) (IHD),The 73rd Annual Scientific Meeting
• 3 Clopidogrel Resistance in Japanese Patients(Current Status and Future Perspective of Antiplatelet Therapy in Management of Coronary Artery Disease,Symposium 2 (SY-02) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation
• OE-316 Implantation of Sirolimus-Eluting Stent in Bifurcation Lesions with Two Stents : 6-month clinical follow-up; Preliminary Results from The j-Cypher Registry(Coronary revascularization,PCI-3 (IHD) OE53, Oral Presentation (English),The 70th Anniversar
• In-hospital Outcomes in Octognenarians with Acute Myocardial Infarction Undergoing Primary Coronary Angioplasty
• Long-term Quantitative Coronary Angiographic Outcome of Palmaz-Schatz Stent Implantation for Native Coronary Arteries
• FRS-022 IGF Axis and Adiponectin as Prognostic Markers in Patients with Congestive Heart Failure(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Serum Adiponectin Level as an Independent Predictor of Mortality in Patients With Congestive Heart Failure
• PE-454 Cell Line-dependent Differentiation of Mouse Induced-pluripotent Stem Cells into Cardiomyocytes(PE076,Regeneration (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
• Expression, Purification and Structural Analysis of Human IL-18 Binding Protein : A Potent Therapeutic Molecule for Allergy
• Sirolimus-Eluting Stent for In-Stent Restenosis of Left Main Coronary Artery in Takayasu Arteritis
• Combined Measurements of Cardiac Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Patients With Heart Failure
• 4 Sirolimus-Eluting Stent Implantation For the Treatment of Unprotected Left Main Coronary Artery Disease : One Year Outcomes from the J-Cypher Registry(Drug-eluting stent, current issues and perspective, The 71st Annual Scientific Meeting of the Japanese
• OJ-084 Risk of Ventricular Tachyarrhythmias Predicted by Biochemical Markers Associated with Cardiac Remodeling(Heart failure, clinical-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Correlation between Cardiac TroponinT and the Other Biochemical Markers in Patients with Myocyte Injury(Heart Failure, Clinical 18 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OE-091 Detection of cardiac sarcoidosis with delayed-enhanced MRI : Comparison with nuclear imaging(X-ray/CT/MRI/DSA 1 (I) : OE11)(Oral Presentation (English))
• 3 Circulating Adiponectin Levels and Coronary Plaques in Patients with Acute Coronary Syndrome : JAPAN-ACS Subgroup Analysis(Late Breaking Clinical Trials II,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OJ-005 Clinical and Angiographic Predictors of Restenosis and Target Lesion Revascularization After Sirolimus-Eluting Stents Implantation in Bifurcations of the j-Cypher Registry.(Coronary revascularization, PCI(05)(IHD),Oral Presentation(Japanese),The 72
• FRS-077 Long-Term Clinical Outcome of Sirolimus-Eluting Stent Implantation in Bifurcations of The j-Cypher Registry : Comparison of Simple versus Complex Stenting Techniques.(Forefront Updates in PCI(02)(IHD),Featured Research Session,The 72nd Annual Scie
• Superparamagnetic Iron Oxide (SPIO) MRI Contrast Agent for Bone Marrow Imaging : Differentiating Bone Metastasis and Osteomyelitis
• Synergistic Effects of Calcium-Channel and Angiotensin-Receptor Blockers on Endothelial Function and Inflammatory Responses in a Porcine Drug-Eluting Stent Model
• FRS-109 A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation(New Horizon in Diagnosis and Pathophysiology of Arrhythmia(A),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
• OE-192 6-Month Clinical Outcome after Implantation of Sirolimus-Eluting Stent in Bifurcation Lesions : Comparison of Simple Versus Complex Strategy(Coronary revascularization, PCI-1 (IHD) OE32,Oral Presentation (English),The 70th Anniversary Annual Scient
• OE-020 Serial Changes of Myocardial Perfusion and Metabolism during Heart Failure Transition in Dahl Rats Using Pin-Hole SPECT System(Nuclear Cardiology 1 (I) : OE3)(Oral Presentation (English))
• Efficacy of Abciximab for Patients Undergoing Balloon Angioplasty : Data From Japanese Evaluation of c7E3 Fab for Elective and Primary PCI Organization in Randomized Trial (JEPPORT)(Ischemic Heart Disease)
• PJ-520 Regionally Different Effect of Complete ST Resolution after Primary PCI for Acute Myocardial Infarction : Myocardial Perfusion, Metabolism, and Cardiac Function(PJ088,ACS/AMI (Clinical/Pathophysiology) 2 (IHD),Poster Session (Japanese),The 73rd Ann
• PJ-519 Anatomical Structure of the Aorto-coronary Junction(PJ087,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 4 Thrombus Aspiration Prior to Primary Coronary Intervention in Patients with ST Elevation Acute Myocardial Infarction. Results of the VAMPIRE Trial(New Horizon in Coronary Interventions for Acute Coronary Syndrome, The 71st Annual Scientific Meeting of t
• The Difference of Myocardial Flow Reserve between Patients with DCM and Dilated Phase of HCM : Evaluation by O-15 Water PET
• Importance of Plasma Catecholamine for the Energy Metabolism in Impaired Myocardium : Experimental Investigation Using I-123 BMIPP
• Importance of Oxidative Metabolism in Regulation of Exercise Tolerance in Patients with Chronic Heart Failure
• Relation among Left Ventricular Mass, Insulin Resistance, and Hemodynamic Parameters in Type 2 Diabetes
• Reversible Cardiomyopathy Associated with Multicentric Castleman Disease : Successful Treatment with Tocilizumab, an Anti-Interleukin 6 Receptor Antibody
• Analysis of Serum Angiogenic Factors in a Young Multiple Myeloma Patient with High-Output Cardiac Failure
• Can Myocardial Oxidative Consumption Regulate the Exercise Tolerance in Patients with Chronic Hear Failure?(Nuclear Cardiology 9 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-112 The Correlation of Myocardial Flow Reserve to the Washout of Tc-99m Sestamibi in Patients With Chronic Heart Failure(Nuclear Cardiology (I) : FRS14)(Featured Research Session (English))
• Exercise Training Improves Energy Metabolism and Normalizes Myosin Heavy Chain Expression of the Reperfused Myocardium in Rats
• Impact of End Stage Renal Disease on Outcomes After Rotational Atherectomy (Rotablator)
• The Na^+-excreting efficacy of indapamide in combination with furosemide in massive edema
• Better Survival With Statin Administration After Revascularization Therapy in Japanese Patients With Coronary Artery Disease : Perspectives From the CREDO-Kyoto Registry
• FRS-021 Contrast-Induced Nephropathy After Percutaneous Coronary Intervention is Associated With High Mortality in Patients With Chronic Kidney Disease : Insights From CREDO-Kyoto(Forefront Updates in PCI(01)(IHD),Featured Research Session,The 72nd Annual
• PJ-735 Comparison of PCI and CABG among Patients with a Chronic Total Occlusion and Multi-vessel Disease : From the CREDO-Kyoto(Coronary revascularization, PCI-19, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-116 Comparison of PCI and CABG in Patients With Multi-Vessel Disease and Reduced Left Ventricular Function : From the CREDO-Kyoto(Coronary Revascularization (clinical) 2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-189 Moderate Mitral Regurgitation is Associated with Long-term Prognosis in Patients with Coronary Artery Diseases Undergone Revascularization(Coronary revascularization, PCI-1 (IHD) OE32,Oral Presentation (English),The 70th Anniversary Annual Scientif
• OE-169 Impact of Atrial Fibrillation on Long-term Clinical Outcome in Patients Undergoing Coronary Revascularization : From CREDO-Kyoto(Arrhythmia, diagnosis/pathophysiology/EPS-1 (A) OE29,Oral Presentation (English),The 70th Anniversary Annual Scientific
• 4 Endovascular Repair with the Inoue Stentgraft for Abdominal and Thoracoabdominal Aortic Aneurysms(Stent-graft for Aortic aneurysms and Dissections:results of clinical application, indication, recent advancement, and future perspective,Meet the Expert 2
• The Role of Serum Dopamine-β-Hydroxylase in Essential Hypertension (3 Conference of Pathogenesis of Hypertension)
• First Preparation and Structural Determination of Optically Pure Cyclic Polysulfides, 6, 10-Diethyl Trithiolo[h]benzopentathiepin Monooxides
• National structure of radiation oncology in Japan with special reference to designated cancer care hospitals
• Long-term outcomes after unprotected left main coronay artery stenting
• Disseminated necrotizing leukoencephalopathy following chemoradiation therapy for acute lymphoblastic leukemia
• Complications After Preoperative Intraluminal Radiotherapy and Radical Surgery for Rectal Carcinoma:A Review of 100 Cases
• Feasibility of unmanipulated haploidentical stem cell transplantation using standard GVHD prophylaxis for HLA-homozygous patients
• Long-term Sequential Changes of Radiation Proctitis and Angiopathy in Rats

もっと見る 閉じる

スポンサーリンク