Better Survival With Statin Administration After Revascularization Therapy in Japanese Patients With Coronary Artery Disease : Perspectives From the CREDO-Kyoto Registry
スポンサーリンク
概要
- 論文の詳細を見る
Background The importance of statins in cardiovascular prevention has been demonstrated in various patient subsets. This study aimed to evaluate the effects of statins on long-term outcomes of Japanese patients undergoing their first coronary revascularization. Methods and Results A total of 9,225 patients undergoing their first coronary revascularizations during 2000-2002 were divided into 2 groups according to the use of statins at discharge; patients with acute myocardial infarction were not included. Statins was administered to only 28.5% (n=2,630) of the patients. The median follow-up period was 3.5 years. Patients on statin therapy showed lower all-cause (5.2% vs 10.0%; p<0.0001) and cardiovascular (3.2% vs 6.2%; p<0.0001) mortality than those without statins (n=6,595) by Kaplan-Meier analysis and log-rank test. After adjustment by multivariate analysis according to 29 variables, statin therapy remained as an independent predictor of reduced all-cause (relative risk ratio (RR) 0.71, 95% confidence interval (CI) 0.59-0.86, p=0.0005) and cardiovascular (RR 0.72, 95% CI 0.56-0.91, p=0.0067) mortality. The validity of RR of statin therapy in multivariate analysis was further confirmed by risk adjustment using propensity scores (all-cause mortality: propensity-adjusted RR 0.70, 95% CI 0.58-0.85, p=0.0003; cardiovascular mortality: propensity-adjusted RR 0.70, 95% CI 0.54-0.89, p=0.0038). Conclusions Statin therapy started at hospital discharge was associated with increased chance of survival in Japanese patients undergoing their first coronary revascularization.
- 社団法人日本循環器学会の論文
- 2008-11-20
著者
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Ehara Natsuhiko
Division of Cardiology, Kobe City Medical Center General Hospital
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Furukawa Yutaka
Division of Cardiology, Kobe City Medical Center General Hospital
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KITA Toru
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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FUKUSHIMA Masanori
Translational Research Center, Kyoto University Hospital, Kyoto University Graduate School of Medici
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Kimura Takeshi
Department of Cardiovascular Medicine, Kyoto University Hospital
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Morimoto Takeshi
Center for Medical Education, Kyoto University Graduate School of Medicine
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Shizuta Satoshi
Department of Cardiovascular Medicine, Kyoto University Hospital
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Yoshino Hideaki
Kyorin University Hospital
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Sato Sumiko
Ehime Prefectural Central Hospital
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Saito Naritatsu
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Doi Takahiro
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Ozasa Neiko
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Haruna Yoshisumi
Division Of Cardiology Department Of Medicine Hirakata Kohsai Hospital
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Furukawa Yutaka
Department Of Cardiology Kobe City Medical Center General Hospital
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Furukawa Yutaka
Division Of Cardiology Kobe City Medical Center General Hospital
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Saito Naritatsu
Department Of Cardiovascular Medicine Kyoto University Hospital
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Hoshino Kouzou
Division Of Cardiology Nagai Hospital
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Ehara Natsuhiko
Department Of Cardiovascular Medicine Kobe City Medical Center General Hospital
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Ehara Natsuhiko
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Doi Takahiro
Department Of Cardiovascular Medicine Kyoto University Hospital
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Ozasa Neiko
Department Of Cardiovascular Medicine Kyoto University Hospital
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Kita Toru
Department Of Geriatric Medicine Graduate School Of Medicine Kyoto University
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HOSHINO Kozo
Division of Cardiology, Nagai Hospital
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Kita Toru
Department Of Cardiology Kobe City Medical Center General Hospital
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Hiasa Yoshikazu
on behalf of j-Cypher Registry Investigators
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Saito S
Division Of Cardiovascular Medicine Keiai Hospital
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TANIGUCHI Ryoji
Division of Cardiology, Hyogo Prefectural, Amagasaki Hospital
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TERAMUKAI Satoshi
Translational Research Informatics Center
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Sunayama Satoshi
Department Of Cardiovascular Medicine Juntendo University School Of Medicine
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Yoshino Hideaki
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Shizuta Satoshi
Department Of Cardiology Juntendo Shizuoka Hospital
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Suwa Satoru
Jyuntendo Izu-nagaoka Hospital
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Furukawa Yutaka
Department Of Cardiovascular Medicine Kobe City Medical Center General Hospital
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Tanaga Kosei
千葉県循環器病センター 循環器科
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Ehara Natsuhiko
Department Of Cardiovascular Medicine Kobe General Hospital
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Saito Nariatsu
Department Of Cardiovascular Medicine Kyoto University
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Saito S
Department Of Cardiology Juntendo Shizuoka Hospital
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Saito Satoshi
日本大学 医学部循環器内科学
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Fukushima Masanori
Translational Research Informatics Center
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Sumida Toshiaki
Translational Research Informatics Center
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Kimura Takeshi
Department Of Cardiology Kobe City Medical Center General Hospital
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Imai Yukiko
Translational Research Informatics Center
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Taniguchi Ryoji
Department Of Cardiovascular Medicine Kyoto University
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Taniguchi Ryoji
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Ehara Natsuhiko
Division Of Cardiology Kobe General Hospital
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Fukushima Masanori
Translational Research Center Graduate School Of Medicine Kyoto University
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Saitoh Naritatsu
Department Of Cardiovascular Medicine Kyoto University
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TSUDA Shouichi
Department of Thoracic and Cardiovascular Surgery Kobe General Hospital
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Ozasa Neiko
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Morimoto Takeshi
Center For Medical Education Graduate School Of Medicine Kyoto University
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Dohmei Takenori
Department Of Cardiology Kokura Memorila Hospital
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Teramukai Satoshi
Translational Research Center Kyoto University Hospital
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Saito Satoshi
Department Of Advanced Medical Science Nihon University School Of Medicine
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Kita Toru
Division Of Translational Research Kyoto Medical Center National Hospital Organization
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Ehara Natsuhiko
Department Of Cardiology Kobe City Medical Center General Hospital
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Doi Takahiro
Department Of Cardiology Kokura Memorial Hospital
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Yoshino Hideaki
Department Of Cardiology Kyorin University Faculty Of Medicine
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Taniguchi Ryoji
Division Of Cardiology Hyogo Prefectural Amagasaki Hospital
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CREDO-Kyoto Investigators
Division of Cardiology, Kobe City Medical Center General Hospital
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MORIMOTO Takeshi
Center for General Internal Medicine and Emergency Care, Kinki University School of Medicine
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KIMURA Takeshi
Department of Applied Chemistry and Molecular Science, Faculty of Engineering, Iwate University
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