Kinetic study on the reaction of p-nitrophenyl acetate with 6-substituted 2,4-diamino-1,3,5-triazines.
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概要
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The reactions of <I>p</I>-nitrophenyl acetate (<B>1</B>) with six 6-substituted 2,4-diamino-1,3,5-triazines, (<B>2a–2f</B>), were kinetically investigated in aqueous DMSO or in water at 30 °C. It was found that the reaction rate <I>R</I> could be expressed according to the equation <I>R</I>=(<I>k</I><SUB>0</SUB>+<I>k</I><SUB>N</SUB>[<B>2</B>])[<B>1</B>], and that Brönsted-type plots for the <I>k</I><SUB>N</SUB>-reaction give a straight line with a slope (β) of 1.05. The solvent deuterium isotope effect was not observed in this reaction [<I>k</I><SUB>N</SUB>(H)⁄<I>k</I><SUB>N</SUB>(D)=1.0–1.15]. Furthermore, the isolated reaction product was 2-acetylamino-4-amino-6-methyl-1,3,5-triazine (<B>4c</B>), which was formed by a nucleophilic attack of <B>2c</B> to <B>1</B>. From these results, the mechanism for this nucleophilic reaction is discussed.
- 公益社団法人 日本化学会の論文
著者
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Kishimoto Koji
Department Of Oral And Maxillofacial Surgery Biopathological Science Okayama University Graduate Sch
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Takagi Yasushi
Department Of Anesthesia Machida Municipal Hospital
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Sato Kenji
Department Of Anatomy And Physiological Science Graduate School Of Health Care Sciences Tokyo Medica
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Sato Hiroyuki
Department Of Biomolecular Science Fac.sci. Toho Univ.
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Konakahara Takeo
Department of Industrial and Engineering Chemistry, Faculty of Science and Technology, Science University of Tokyo
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Konakahara Takeo
Department of Applied Chemistry, Science University of Tokyo
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Takagi Yasushi
Department of Industrial and Engineering Chemistry, Faculty of Science and Technology, Science University of Tokyo
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