3. 下垂体性腺系 (女子)

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Observing the hormonal secretion of the anterior lobe of pituitary in women, gonadotropin increases significantly in the climacteric and senile period, particularly in FSH, as compared to the reproductive period. While TSH, ACTH, GH remain unchanged and PRL decreases slightly. In general it would seem that the elevated gonadotropin level is well sustained throughout the remainder of life even past the age of 80. Concerning the ability of the secretion of steroid hormone in the ovary, estradiol is gradually reduced through the premenopausal period, and testosterone is inversely increased. This pattern becomes more apparent after the menopause. It seems to have the same tendency of cyclic-AMP and steroid dehydrogenase in the ovary. However, estradiol in peripheral blood decreases slightly during the senile period, also testosterone decreases gradually with aging. It means testosterone secreted by the ovary seem to have converted into estradiol in other organs. TeBG has no definite evidence of any relation to the process of aging. Furthermore DHA and DHA-S have a tendency to decrease. However, there is no significant change in cortisol with aging. During the past 20 years, there has been a tendency of menarche occuring at an earlier age, and particularly menopause beginning at a later age. Estradiol receptor in the uterus has sustained well in qualitative reactivity even in old age. The loss of balance between sexual desire and sexual intercourse is gradually aggravated with aging. It seems that psychotropics rather than estradiol has a greater meaning in regard to the sexual activity of the aged rat. Therefore this provides us a clue that women seem to have a necessity of an emotional adjustment in their sexual life on the process of aging.

3. 下垂体性腺系 (女子)

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