1.エストロゲン代謝とその臨床的意義

概要

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In order to clarify the clinical significance of estrogen, it seems of value to investigate the biosynthesis, metabolism and transport of estrogen in pre- and postmenopausal women. More production of estrogen from testosterone (T), Δ4-androstenedione and dehydroepiandrosterone (DHEA) in human ovary was found in premenopausal group than in postmenopausal group, yielding higher ratio of estradiol-17β (E2) fraction than estrone (E1) fraction. Estriol (E3), however, was not identified in these products. The reversible change between E1 and E2 was not proved in the ovary. A slight production of E1 and E3 in the human liver resulted from DHEA in premenopausal group and no production of estrogen from T was found in both pre- and postmenopausal groups. In the liver some conversion of E1 and E3 from E2 was proved. More amount of the remained E2, largely composed of liberated and conjugated forms, was found in premenopausal group. In post-menopausal group, more conjugated form of E2 was found than in premenopausal group. In the human kidney, a little production of E1 from T and E2 was observed. The ratio of E2 binding to plasma protein was higher in premenopausal group and in secretory phase of the menstrual cycle. The binding power to plasma protein is stronger in E, than in E1. No significant difference was observed in the ratio of E1-binding to plasma protein in both groups. A higher yield of E2 from E2-glucosiduronate in the endometrial tissue was obtained with a buffer solution of pH 5.7 than with that of pH 7.2. The application of dexamethasone to castrated women resulted in a decrease of urinary estrogens and a subsequent application of E2 brought about a slight increase of urinary E1 and significant increase of urinary E2, particularly in those castrated in premenopausal period. The results suggest that E2 plays an important roll in the genital organs and E1 in the extra-genital organs.
日本内分泌学会の論文

著者

森一郎
鹿児島大学産婦人科

1.エストロゲン代謝とその臨床的意義

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