Thyroxine-binding globulin (TBG) 減少症の一家系

概要

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Partial thyroxine-binding globulin (TBG) deficiency in a family is described. A 43-year-old male was admitted because of the association of low thyroxine level but markedly elevated triiodothyronine resin-uptake despite his complaints of palpitation and excessive sweating. TBG was low (6 μg/ml) by radioimmunoassay. His free thyroxine level was normal. <SUP>123</SUP>I uptake at 24 hours was normal and was suppressed following oral administration of triiodothyronine. Serum TSH level was normal and responded normally to TRH stimulation. Similar low level (6 μg/ml) in TBG was found in his elder brother who had no complaints. Another brother and 3 sisters had normal TBG levels.<BR>According to the classification of the TBG deficiency proposed by Barbosa et al., a family described here is considered to have the type II TBG deficiency which shows a much lower TBG level in male than in female with X-linked inheritance.
日本内分泌学会の論文