正常月経周期, 妊娠, 閉経後および外陰ジストロフィーにおける血中free testosteroneの測定

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It is considered that plasma-free testosterone is a bioactive androgen in blood and is more reflective in androgenicity than plasma total testosterone. We measured plasma-free testosterone by dializable method in normal menstrual females, pregnant females, post menopausal females and vulvar dystrophy.<BR>The values of plasma total testosterone (T), fractional free testosterone (%FT) and plasma-free testosterone (free T) were 0.61 ± 0.27 (mean ± SD) ng/ml, 1.19 ± 0.34% and 0.61 ± 0.20ng/dl in the follicular phase of normal menstrual females (n=25), and 0.57 ± 0.23ng/ml, 1.29 ± 0.46% and 0.56 ± 0.35ng/dl in the luteal phase of normal menstrual females (n=24), respectively. The values in both phases showed no differences from each other. In post menopausal females (n=18), the concentration of T (0.36 ± 0.27ng/ml) and free T (0.52 ± 0.12ng/dl) was significantly lower (T : P<0.01, free T : P<0.05) than that in normal menstrual females. However, %FT in post menopausal females (1.37 ± 0.12%) was not different as compared with that in normal menstrual females. In pregnant females (n=2) of second and third trimester, T (0.53 ± 0.07ng/ml) was not different as compared with that in normal menstrual females, but %FT (0.67 ± 0.45%) and free T (0.33 ± 0.23ng/ dl) were significantly lower (P<0.05) than in normal menstrual females.<BR>In vulvar dystrophy, lichen sclerosus (n=19) and hyperplastic dystrophy without atypia (n=12) were measured. In these patients, T, %FT and free T were 0.82 ± 0.22ng/ml, 1.54 ± 0.88% and 1.33 ± 0.46 ng/dl in lichen sclerosus, and 0.76 ± 0.35ng/ml, 1.10 ± 0.22% and 0.95± 0.50ng/dl in hyperplastic dystrophy without atypia, respectively. T and free T in these patients were significantly higher (T : P<0.01, free T : P<0.05) than in post menopausal females. However, %FT was not different as compared with that in post menopausal females.
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正常月経周期, 妊娠, 閉経後および外陰ジストロフィーにおける血中free testosteroneの測定

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