Biomimetic One-Pot Preparation of a Black Tea Polyphenol Theasinensin A from Epigallocatechin Gallate by Treatment with Copper(II) Chloride and Ascorbic Acid
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概要
- 論文の詳細を見る
Chromatographic separation of black tea polyphenols is too difficult to supply sufficient quantities of pure compounds for biological experiments. Thus, facile methods to prepare black tea constituents were desired. Treatment of epigallocatechin gallate with copper(II) chloride efficiently afforded an unstable quinone dimer, dehydrotheasinensin A, and subsequent treatment with ascorbic acid stereoselectively yielded theasinensin A. The latter is a dimer with an R-biphenyl bond, one of the major polyphenols found in black tea. The method is simpler and more effective than enzymatic preparation.
- The Pharmaceutical Society of Japanの論文
著者
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松尾 洋介
長崎大学大学院医歯薬学総合研究科
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Matsuo Yosuke
Graduate School Of Biomedical Sciences Nagasaki Univ.
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KOUNO Isao
Graduate School of Biomedical Sciences, Nagasaki University
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Kouno Isao
Graduate School Of Biomedical Sciences Nagasaki Univ.
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Tanaka Takashi
Graduate School Of Biomedical Sciences Nagasaki University
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Shii Takuya
Graduate School of Biomedical Sciences, Nagasaki University
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Miyamoto Makoto
Graduate School of Biomedical Sciences, Nagasaki University
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Tanaka Takashi
Graduate School Of Biochemical Science Nagasaki University
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Matsuo Yosuke
Graduate School of Biomedical Sciences, Nagasaki University
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Kouno Isao
Graduate School of Biomedical Sciences and School of Pharmaceutical Sciences, Nagasaki University
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