Studies on the Clinical Feasibility of Keigai-Rengyo-To for Chronic Sinusitis.

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A clinical study was conducted on the feasibility of herbal medicine TJ-50 (Tsumura Keigai-rengyo-to) in treating chronic sinusitis. Thirty-nine patients were enrolled in this study (male 16, female 23), ranging from 16 to 86 years old.In all patients, Keigai-rengyo-to was administered orally three times daily for four to eight weeks. A higher rate of improvement in subjective symptoms were observed for postnasal drip, rhinorrhea and nasal obstruction, as well as for postnasal drip and volume of nasal mucus on rhinoscopic findings. When evaluation was based on both subjective symptoms and objective findings, 28 of 38 (73.7%) cases were graded as "slightly effective" or higher. This improvement rate was higher in the patient group with less than 12 months duration of chronic sinusitis. On X-ray findings of the paranasal sinuses, seven of 23 (30.4%) cases were graded "slightly effective". No patient attained the grade "effective" or "markedly effective". As to the clinical feasibility of Keigai-rengyo-to, judged from the above evaluations and safety due to fewer potential side effects, the grad "useful" was obtained in ten of 39 cases (25.6%) and more than "slightly useful" in 22 of 39 cases (56.4%). Side effects were observed in one case of eruptions which disappeared after treatment was discontinued, and in two cases of gastric symptoms.Gastric symptoms were mild, and were alleviated as the treatment was continued.
耳鼻咽喉科臨床学会の論文