副鼻腔炎に対するホスホマイシンの経口投与による臨床効果ならびに血中および組織内濃度の推移の検討

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Five patients with acute sinusitis, 2 with chronic sinusitis and 5 with acutely aggravated chronic sinusitis, for a total of 12 patients, were orally administered fosfomycin to investigate the efficacy and side effects. As a result, the efficacy rate was 83.3% according to the criteria for evaluation of the degree of improvement by the physician-in-charge. According to the standard criteria for evaluation, the efficacy rate was 91.7% for the objective and subjective evaluations, 83.3% for the improvement in X-ray findings, 72.2% for bacterial elimination and 72.2% for global evaluation. No side effects were observed in any of the patients. From these results, fosfomycin was considered to be a clinically safe and excellent drug. By administering the drug preoperatively, we also investigated the changes in the serum and tissue levels in 9 patients with chronic sinusitis during the course of radical surgery on the maxillary and ethmoidal sinuses.
耳鼻咽喉科臨床学会の論文