鼻アレルギ-に対するアゼラスチンの効果

概要

論文の詳細を見る
The effectivenes and safety of Azeptin® (azelastine hydrochloride) were examined in 151 patients with perennial and seasonal allergic rhinitis after oral administration of 1mg twice daily for more than 2 weeks. Slight to marked improvement occurred in 93.1% of the perennial and in 91.5% of the seasonal group. Since there was almost nodiffeerence between the two, in the present statistical study, they were dealt with as one group. The overall effectiveness was 92.7%. Slight to high usefullness was recorded in 93.3%. Improvement was greatest in the following groups: older patients, those with a 5 to 10 year history of symptoms, those with sneezing, the group treated for 6 to 8 weeks, and the group with eosinophils in the nasal discharge. Side effects were noted in 4 patients (2.6%), but the symptoms were slight and did not interfere with ordinary life. The present study showed that in a dose of 1mg twice daily for more than 2 weeks, Azeptin® has a definite inhibitory effect on both perennial and seasonal allergic rhinitis and is a safe medicine.