A randomized, controlled trial of bacampicillin vs. cephalexin in the treatment of acute purulent otitis media.

概要

論文の詳細を見る
1) The relationship between the expected efficacy index (EEI) and the clinical efficacy of bacampicillin (BAPC) and cephalexin (CEX) in the treatment of acute suppurative otitis media was studied.2) Fifty-nine patients were analyzed, 27 treated with BAPC and 32 treated with CEX.3) The clinical efficacy was judged by the clinician to be excellent in 66.7% of the BAPC group and in 31.3% of the CEX group. This difference was statistically significant (p<0.05). As judged by the committee criteria, the clinical response was significantly (p<0.05) better in the BAPC group, (88.9%) that in the CEX group (62.5%).4) The bacteriological efficacy, expressed by the eradication rate 3 and 7 days after treatment, was 65.4% and 100% in the BAPC group, and 41.9% and 90.3% in the CEX group.5) No adverse reactions were observed in either group.6) The EEI calculated from ( ) and ( ) disk method sensitivity was 93.5 with BAPC and 82.4 with CEX. If only ( ) was taken as sensitive, it was 86.9 with BAPC and 59.0 with CEX. The EEI calculated from the MIC method was 89.1 with BAPC and 64.9 with CEX.The clinical response as evaluated by the committee criteria showed a good correlation with the EEI value calculated from both ( ) disk sensitivity and the MIC method.These results indicate that the EEI concept is useful for selecting antibiotics in the treatment of acute suppurative otitis media.
耳鼻咽喉科臨床学会の論文