嫌気性菌検出慢性中耳炎とその薬剤感受性(河村正三教授開講10周年記念論文)

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1) Two cases of chronic otitis media are reported. Anaerobic bacteria were found in both cases.The first case concerns a 32 year old woman who complained of hearing disturbance of a long duration and an aural discharge. Nature of the aural discharge was pus and fetid secretion. She had been suffering from recurrent postoperative middle ear infection with granulation and narrowing of the external ear canal. Four kinds of anaerobic bacteria were found in her ear discharge. These bacteria were Peptococcus, Fusobacterium, Bacteroides and micro-anerobic streptococcus. After treatment with Lincomycin, the fetid aural discharge disappeared.The second case was a 34 year old man.He complained of left earache, left ear discharge and vertigo. Surgical intervention revealed that the patient have advanced chronic otitis media with cholesteatoma.Four kinds of anaerobic and 3 kinds of aerobic bacteria were found.Anaerobic bacteria were Bacteroides, Fusobacterium, Peptococcus and Clostridium. Inoculum size of these anaerobic bacteria was numerous and aerobic bacteria were few.2) Antimicrobial agents were studied. Eighty-one strains were recovered from 62 patients with chronic otitis media. The three-disc method with Petri dishes was used for the antimicrobial agents susceptibility test.The results were as follows:Peptococcus have a considerable sensitivity for many different antibiotics except Kanamycin and Gentamicin. Bacteroides were resistant to PCG, MCIPC, ABPC, SBPC, CER, KM, GM, and EM. On the other hand, Bacteroides were highly sensitive to CP and LCM.Our conclusion is that CP should be used as the first choice antibiotic for anaerobic ear infection.
耳鼻咽喉科臨床学会の論文

嫌気性菌検出慢性中耳炎とその薬剤感受性(河村正三教授開講10周年記念論文)

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