上気道炎分離株に対するセフェム系抗生剤の抗菌力ならびに組織内濃度の検討

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The usefulness of cefmetazole (CMZ), a cephem antibiotic, in the treatment of upper respiratory tract infections was assessed in respect to antibacterial activity and antibiotic concentrations in tissues.The in vitro antibacterial activity was determined by the re-revised minimum inhibitory concentration (MIC) assay procedure of the Japanese Society of Chemotherapy. For estimation of tissue antibiotic concentrations, specimens of the palatine tonsilla and maxillary sinus mucosa obtained at operation from patients given an intravenous dose of 1-2g of CMZ or cefazolin (CEZ) were assayed by the thin agar layer-cup method and sensitivity disc method, using Micrococcus luteuss ATCC 9341 or Bacillus subtilis ATCC 6633 as the test organism, respectively.Results:1) The antimicrobial susceptibility tests revealed an increased activity against Haemophilus influenzae and indole-positive Proteus isolates.2) There was a remarkable proximity of the MIC and minimum bactericidal concentration (MBC) of CMZ against the various clinical isolates in vitro.3) Ten to 40% of the serum level of CMZ were demonstrated in the maxillary sinus mucosa and palatine tonsils. These tissue levels sufficiently surpassed the MICs of frequent isolates from upper respiratory tract infections.4) The tonsil level of CEZ, another cephem antibiotic, was about t he same as that of CMZ, but the rate of transfer from the serum to tonsils was less variable in the case of CEZ.The results indicate considerable usefulness of CMZ in the treatment of upper respiratory tract infections.
耳鼻咽喉科臨床学会の論文

上気道炎分離株に対するセフェム系抗生剤の抗菌力ならびに組織内濃度の検討

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