Rifampicinの免疫抑制作用について-1-遅延型アレルギー,マクロファージ,多核球のenzyme activityに及ぼす影響

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0.4 ml of an emulsion containing 25 mg of 2% phenolized BCG per milliliter was prepared with equal amount of steril saline and incomplete Freund adjuvant.0.1 ml of its portions were injected into all four foot-pads of the guinea pigs. From the same day of the above immunization, Rifampicin (RFP) 100 mg/kg in propylenglycol (propy. ) was injected into the muscle of guinea pigs daily for 16 days and the saline or propylenglycol alone was injected as the control. Tuberculin testing (old tuberculin diluted 1: 10) was done 12 days and 16 days after immunization and the intensity of the reaction was expressed as a volume of the reaction by multiplying the reaction area with thickness. A volume of tuberculin reaction in the RFP, propy. and saline groups is 223.8±49.2 mm3, 1, 367.6±202.6 mm3 and 1, 428±197.6 mm3, respectively, and supressive effect on tuberculin reaction by RFP was observed obviously. (Table 1)
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