The Assay of Ascorbic Acid in Serum Is Not Affected by Physiological Concentrations of Transferrin and Hemoglobin
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概要
- 論文の詳細を見る
Transferrin and hemoglobin have been reported to oxidize L-ascorbic acid (AA) in vitro. The aim of this study was to determine whether or not physiological concentrations of serum transferrin (reference range 22-45μmol/L) and hemoglobin (reference range 0-3.0μmol/L) interfer with the measurement of AA in the serum. Transferrin (33 to 41μmol/L) and hemoglobin (1.9μmollL) added to freshly pooled serum significantly decreased measured AA in the serum (p<0.05). However, we found that the magnitude of the decrease in AA due to transferrin at concentrations within the reference range or up to 80μmol/L was inconsequential, and had no clinical importance in diagnosing a low AA concentration. Hemoglobin at concentrations within the reference range had little affect on the serum AA measurement. However, when serum specimens were stored at 4°C for more than 1.5h, the magnitude of the decrease in AA due to hemoglobin at physiological concentrations may cause a misleading clinical diagnostic evaluation of low AA concentration.
- 財団法人 学会誌刊行センターの論文
- 2003-08-01
著者
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HASHIZUME Naotaka
Departments of Laboratory Medicine, Ohashi and Omori Hospitals, School of Medicine, Toho University
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Ihara H
Department Of Laboratory Medicine Ohashi Hospital School Of Medicine
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Ihara Hiroshi
Department Of Laboratory Medicine Ohashi Hospital Toho University School Of Medicine
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Ihara Hiroshi
Departments Of Laboratory Medicine Ohashi And Omori Hospitals School Of Medicine Toho University
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Hashizume Naotaka
Department Of Laboratory Medicine Ohashi Hospital School Of Medicine
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Hashizume Naotaka
Department Of Laboratory Medicine Ohashi Hospital Toho University School Of Medicine
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Hashizume Naotaka
東邦大学医学部附属大橋病院検査部
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Hashizume Naotaka
Department Of Clinical Pathology School Of Medicine Teikyo University
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Sumiyama Yoshinobu
Toho University Ohashi Medical Center Hospital Third Department Of Surgery
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Hirano Akiko
Department Of Biomolecular Science Faculty Of Science Toho University
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Okada M
Department Of Biomolecular Science Faculty Of Science Toho University
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SHINO Yoshio
Department of Laboratory Medicine, Ohashi Hospital, School of Medicine
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Okada Mitsumasa
Department Of Biochemistry Faculty Of Science University Of Tokyo
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IHARA Hiroshi
Department of Laboratory Medicine Ohashi Hospital
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SHINO Yoshio
Department of Laboratory Medicine Ohashi Hospital
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