The Significance of Plasma Lysophospholipids in Patients with Renal Failure on Hemodialysis
スポンサーリンク
概要
- 論文の詳細を見る
Abnormal phospholipid metabolism may play an important role in the progression of atherosclerosis in renal failure. We analyzed plasma phospholipid and lysophospholipid contents and fatty acid composition in the phospholipids of 18 patients with renal failure on hemodialysis (HD) and compared the levels with those of healthy controls. HD patients had a notably higher molar ratio of the plasma lyso-phosphatidylcholine (lysoPC)/phosphatidylcholine (PC) distributed from 0.072 to 0.207, and the control group showed a ratio lower than 0.150. Plasma phosphatidylethanolamine (PE) concentration significantly increased in HD patients compared with control subjects. A much higher level of plasma lysophosphatidic acid (lysoPA) (1.41±0.16nmol/mL) was observed in HD patients compared with controls (0.54±0.08 nmol/mL). A strong correlation was found between plasma lysoPA and lysoPC concentrations (r=0.609, p<0.01) in HD patients. Serum inorganic phosphate (P) concentration was associated with the abnormal plasma lysoPC/PC, PE, and lysoPA levels in HD patients. Important decreases in eicosapentaenoic acid (EPA) of plasma PC and of dietary intake were observed in HD patients. Plasma thiobarbituric acid reactive substance (TBARS) concentration was negatively correlated with the amount of vitamin E intake in both subjects. These findings demonstrated the specific characteristics of the abnormal phospholipid metabolism in HD patients. The cause and consequences of elevated lysoPC/PC molar ratio and lysoPA in the plasma of HD patients remain to be established.
- 財団法人 学会誌刊行センターの論文
著者
-
Okita Misako
Department Of Food Science And Nutrition Nara Women's University
-
SASAGAWA Takayo
Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural Univer
-
Suzuki Kazuhiko
Department Of Electrical Engineering Hokkaido Institute Of Technology
-
SHIOTA Tetsuya
Division of Internal Medicine, Hukuwatari Hospital
-
KONDO Tadaaki
Division of Internal Medicine, Shigei Hospital
-
Sasagawa Takayo
Department Of Nutritional Science Faculty Of Health And Welfare Science Okayama Prefectural Universi
-
SASAGAWA Takayo
Department of Nutritional Science, Faculty of Health and Welfare Science
関連論文
- Fibrinoid Leukodystrophy (Alexanders Disease-Like Disorder) in a Young Adult French Bulldog
- Sandwich Enzyme-linked Immunosorbent Assay System for Micro-detection of the Wheat Allergen, Tri a Bd 17 K(Food & Nutrition Science)
- Plasma Fatty Acid Composition, Estimated Desaturase Activities, and Intakes of Energy and Nutrient in Japanese Men with Abdominal Obesity or Metabolic Syndrome
- Electrical Properties of Regrowth ZnSe Homointerfaces Formed by Molecular Beam Epitaxy
- Electrical Properties of ZnSe/ZnSe Homointerfaces Formed by MBE Regrowth Process
- Characterization of Epitaxial ZnSe/GaAs(100) Interface Properties and Their Control by (HF+Se)-Pretreatment
- Characterization and Control of MBE-ZnSe/GaAs(100) Substrate Interface and Regrown ZnSe/ZnSe Homointerface
- Control of oxidative stress and reduction in biochemical markers by Vitamin E treatment in patients with nonalcoholic steatohepatitis : a pilot study
- Zinc Supplementation Prevents the Increase of Transaminase in Chronic Hepatitis C Patients during Combination Therapy with Pegylated Interferon α-2b and Ribavirin
- Dietary Intake, Neutrophil Fatty Acid Profile, Serum Antioxidant Vitamins and Oxygen Radical Absorbance Capacity in Patients with Ulcerative Colitis
- Effects of Eicosapentaenoic Acid Supplementation in the Treatment of Chronic Hepatitis C Patients
- Serum Cytokeratin 18 M30 Antigen Level and Its Correlation with Nutritional Parameters in Middle-Aged Japanese Males with Nonalcoholic Fatty Liver Disease (NAFLD)
- Continuous Conversion to Optically Pure L-Methionine from D-Enantiomer Contaminated Preparations by an Immobilized Enzyme Membrane Reactor
- T-2 TOXIN INDUCED APOPTOSIS IN RAT KERATINOCYTE PRIMARY CULTURES(Mycotoxins, Proceedings of the 32nd Annual Meeting)
- Analysis of Syk Expression in Bovine Lymphoma and Persistent Lymphocytosis Induced by Bovine Leukemia Virus
- Fetally Derived CCL3 is Not Essential for the Migration of Maternal Cells Across the Blood-Placental Barrier in the Mouse
- Effects of GaAs Surface Pretreatment and Post-Growth Annealing on Interface Properties of MBE-ZnSe/GaAs(Sub.) System
- Doping-Induced Defects in P-Doped Photo-CVD a-Si:H
- Characterization of Photo-CVD a-Si:H Films by Thin-Film Transistor Structure
- Chronic hepatic disease and dietary instruction
- Characterization of μc-Si:H Prepared by Photo-Chemical Vapor Deposition
- Evolution of Transport Properties along a Semi-Insulating CdTe Crystal Grown by Vertical Grandient Freeze Method
- Phosphorus Doping Properties of Hydrogenated Amorphous Silicon Prepared by Mercury Sensitized Photo-CVD : Condensed Matter
- The Significance of Plasma Lysophospholipids in Patients with Renal Failure on Hemodialysis
- Fatty Acid Composition and Arachidonate Metabolites in the Livers of Ethanol-Treated Rats Fed an Arachidonate-Supplemented Diet: Effect of Dietary Fat
- Effect of Arachidonate on Lipid Metabolism in Ethanol-Treated Rats Fed with Lard
- 5-Azacytidine-induced Apoptosis in Lymphoid and Hematopoietic Organs of Adult Mice
- Development of Apoptosis and Changes in Apoptosis-Related Genes Expression in the Thymus of Nivalenol-Treated Mice
- Renal Tubulointerstitial Lesions in Mercuric Chloride-Treated F344 Rats
- n-3 and n-6 Fatty Acid Intake and Serum Phospholipid Fatty Acid Composition in Middle-Aged Women Living in Rural and Urban Areas in Okayama Prefecture.
- Modeling and stage-to-stage computation of multicomponent distillation processes as a multistage optimization problem.