Membrane stabilizing effect of vitamin E: Existence of a hydrogen bond between .ALPHA.-tocopherol and phospholipids in bilayer liposomes.
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概要
- 論文の詳細を見る
In order to elucidate the existence of a hydrogen bond between α-tocopherol and phospholipids in bilayer liposomes, the effects of the presence or absence of α-tocopherol or its acetate on either the permeability of liposomes to chromate ions or the fluidity of liposomes composed of the different kinds of lecithin [egg yolk phosphatidylcholine (EPC), 1-oleoyl-2-palmitoylphosphatidylcholine (OPPC), or 1-O-oleyl-2-O-palmitylphosphatidylcholine (OPPCE)] were examined. From the results obtained, it was concluded that the hydroxyl group of α-tocopherol is hydrogen bonded to the carbonyl group of a fatty acid ester in the phospholipids of bilayer liposomes in order to retain α-tocopherol molecule in the space close to the surface of membranes formed by the unsaturated fatty acid moiety of phospholipids.
- 財団法人 学会誌刊行センターの論文
著者
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松尾 光芳
Tokyo Metropolitan Institute of Gerontology
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浦野 四郎
Tokyo Metopolitan Institute of Geronotology
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浦野 四郎
Tokyo Metropolitan Institute of Gerontology
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長谷川 由里
Tokyo Metropolitan Institute of Gerontology
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北原 美樹
Tokyo Metropolitan Institute of Gerontology
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加藤 優子
Tokyo Metropolitan Institute of Gerontology
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