The Radical-Scavenging Reactions of a Vitamin E Model Compound, 2,2,5,7,8-Pentamethylchroman-6-ol, with Radicals from the Fe (II)-Induced Decomposition of a Linoleic Acid Hydroperoxide, (9Z, 11E)-13-Hydroperoxy-9,11-octadecadienoic Acid
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概要
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The radical scavenging reactions of a vitamin E model compound, 2,2,5,7,8-pentamethylchroman-6-ol, with radicals from the Fe (II)-induced decomposition of a linoleic acid hydroperoxide, (9Z, 11E)-13-hydroperoxy-9,11-octadecadienoic acid, were examined extensively. When Fe (II) was added to a mixture of the vitamin E model compound and the linoleic acid hydroperoxide in methanol, (9E)-trans-12,13-epoxy-erythro-11-, (9E)-trans-12,13-epoxy-threo-11-, (9Z)-trans-12,13-epoxy-erythro-11-and (9Z)-trans-12,13-epoxy-threo-11-(2,2,5,7,8-pentamethylchromanoxy)-9-octadecenoic acids, and (9E)-13-hydroxy-12-methoxy-11-(2,2,5,7,8-pentamethylchromanoxy)-9-, (10E)-13-hydroxy-12-methoxy-9-(2,2,5,7,8-pentamethylchromanoxy)-10-and (11E)-13-hydroxy-10-methoxy-9-(2,2,5,7,8-pentamethylchromanoxy)-11-octadecenoic acids were obtained as main products. The hydroxymethoxy acids are presumed to be derived from the epoxy acids. A possible reaction pathway for the formation of the products is discussed.
- 公益社団法人日本薬学会の論文
- 1985-05-25
著者
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金子 孝夫
東京都老人研
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松尾 光芳
Tokyo Metropolitan Institute of Gerontology
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松尾 光芳
甲南大・理
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金子 孝夫
Tokyo Metropolitan Institute of Gerontology
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