Childhood pemphigus vulgaris with first manifestation of intractable stomatitis:Report of a case.

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A rare case of pemphigus vulgaris that occurred in a 5-year-old girl is presented. She was referred to our hospital with a chief complaint of painful and intractable erosion of oral mucosa, and this lesion was clinically diagnosed as intractable ulcerative stomatitis.<BR>Histopathological and immunohistochemical examinations of a lip mucosa biopsy specimen revealed acantholysis of oral epithelium and presence of IgG and IgA in the intercellular epithelial region. Thus, it was diagnosed as pemphigus vulgaris.<BR>The patient was admitted to the Department of Dermatology, Osaka University Hospital, and administered prednisolone per os at a dose of 20 rug daily. Six months after the oral manifestation, skin lesions appeared at the abdominal region. Both oral and skin lesions were markedly improved by prednisolone administration. She has no symptoms by maintaining a dose of 10mg/day of prednisolone.
社団法人日本口腔外科学会の論文