Clinical study on concentration of cefazolin(CEZ) in maxillary bone tissue.

概要

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For a clinical application of Cefazolin (CEZ, Cefamezin (R) ) in the maxillofacial region, CEZ 2g was administered by intravenous drip infusion to 26 patients and a pharmacokinetic analysis was performed for CEZ concentrations in the mandibular and maxillary bones. The serum concentration of CEZ was 82.0 μg/ml after 1 hour, 46.8 μg/ml after 2 hours, 15.3 μg/ml after 4 hours and 5.0 μg/ml after 6 hours. The half life of CEZ in the serum was 1.24 hour. The concentration of CEZ in the bone was 5.7 μg/mg after 1 hour, 4.0 μg/mg after 2 hours, 2.0 μg/mg after 4 hours and 1.0 μg/mg after 6 hours. The half life of CEZ in the bone was 1.99 hour. The concentration in the bone relative to that in the serum ranged from 6 to 20%. As for the intraosseous concentration and MIC80 values of bacteria, the former exceeded the latter in most bacterial strains. The above results suggest that CEZ is useful for the treatment of various infections in the maxillofacial regions.