シクロスポリン投与患者における歯肉増殖症の発現とシクロスポリン投与量および口腔衛生状態の関連について

概要

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Recently, cyclosporin-A (Cy-A) induced gingival hyperplasia has been reported. We examined the oral condition of 8 patients with kidney transplants who were administered Cy-A at Tottori Prefectural Central Hospital, and found gingival hyperplasia in 3 patients. We studied the total dose and duration of Cy-A treatment in the 8 patients. In the group with gingival hyperplasia, the mean total dose given until gingival hyperplasia appeared was 2, 433.2 mg/kg, and the mean period until gingival hyperplasia appeared was 744.3 days. In the group without gingival hyperplasia, the mean total dose was 5, 462.7 mg/kg, and the mean period of treatment was 1, 278.6 days at the time of the study. Oral hygiene was evaluated by the Oral Hygiene Index-Simplified (OHI-S). In the group with gingival hyperplasia, the mean OHI-S score was 3.66, while in the group without gingival hyperplasia, the mean OHI-S score was 1.65. No correlation was found between gingival hyperplasia and either the total dose or the duration of Cy-A treatment. A significant correlation was found between gingival hyperplasia and oral hygiene.