Study of oral and other tissue distribution of cefbuperazone(CBPZ).

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CBPZ was injected into rabbits at a dose of 40mg/kg body weight intravenously. The degree of shift to extraoral and intraoral tissue and serum concentration were examined. Then it was investigated for the influence which the difference in week-aged of rabbits exerted upon them. 1. Cmax of intraoral tissues in adult rabbits were high in the order of the gingiva, parotid gland, buccal mucosa, tongue, submandibular salivary gland and alveolar part of the upper jaw. In infant rabbits the level was higher in the parotid gland than in the gingiva. 2. Cmax of extraoral tissue in adult rabbits were high in the order of the kidney, liver, skin, bone marrow of the femur, spleen, muscle and cortex of the femur. In infant rabbits the level was higher in the bone marrow of femur than in skin. 3. Cmax of the gingiva in both adult and infant rabbits were similar to those of skin. Cmax of alveolar part of upper jaw were about median values of bone marrow and cortex of femur bone. The values of Cmax of the tonge were several times higher than in the femoral muscle. 4. Tmax of intraoral tissues were 5-8 minutes in adult rabbits and 4-5 minutes in infant rabbits. T 1/2 of intraoral tissue were 30-40 minutes in adult rabbits and 40 minutes in infant rabbits. 5. T 1/2 in serum were 25.4 minutes in adult rabbits and 35.1 minutes in infant rabbits. 6. Serum concentrations in infant rabbits were low compared with adult rabbits. The concentrations of intra and extraoral tissues except in the bone marrow of the femur tended to the same results.

Study of oral and other tissue distribution of cefbuperazone(CBPZ).

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