Clinical evaluation of Cefmetazole (CMZ) in the field of oral surgery.

概要

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The effect and safety of Cefmetazole was evaluated in 86 cases treated prophilactically after surgery. Furthermore, 45 cases with oral infections were treated with the drug. Bacteria were isolated from the infectious lesions and their sensitivities to antibiotics were tested. The results could be summarized as follows: 1. Clinicl effects of Cefmetazole in 45 cases of infectious group were excellent in 7 cases, good in 28 and poor in 10, the effectiveness rate being 77. 8 %. No occurrence of infection was noted in the 86 cases prophilactically treated with Cefmetazole after surgery. 2. Bacteriological examinations were carried out for 23 cases with infectious disease and isolated in 18 cases (78 %). There were 29 isolated strains, 55.6 % of which were anaerobic. Antibiotic-susceptibility test showed that all isolated aerobic and anaerobic bacteria except Enterococcus faecalis were highly sensitive to Cefmetazole. 3. Side effects noted were mild eruption in 3 cases, slight stomach discomfort in 1 case and diarrhea in 1 case, but no other abnormality was observed. 4. In laboratory findings, the slight elevation of GOT and eosinophilia were observed, although these values returned to normal immediately after therapy. According to these result, Cefmetazole was evaluated to be a useful antibiotics on prevention of infection after surgery and various infections in the field of oral surgery.
社団法人日本口腔外科学会の論文