新しい光感受性色素 (フェオフォバイド-a) を用いた口腔癌細胞に対する光力学療法の基礎的研究

概要

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We have already shown that photodynamic therapy using of a new photosensitizer, pheophorbide-a (Ph-a) would be useful for cancer treatment.<BR>In this report, we have studied the sensitivity to Ph-a in 5 cancer cell lines which were derived from the oral region.<BR>It has been revealed that oral squamous cell carcinoma (SCC) cells were shown to be more sensitive to Ph-a in comparison to salivary gland-derived adenocarcinoma (SAC) cells. The SCC cells which were sensitive to Ph-a demonstrated an increased intra-cellular level of Ph-a in comparison to SAC cells. These results indicate that the accumulation of Ph-a in the cells should reflect to the cytotoxity. In addition to these findings, it was revealed that SCC cells exhibited an increased level of reduced glutathione (GSH), glutathione peroxidase (GSH-Px) activities, and glutathione S-transferase (GST) activities in comparison to SAC cells.