口腔領域悪性腫瘍組織における上皮成長因子受容体 (Epidermal growth factor receptor) の発現

概要

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We have generated a monoclonal antibody to the epidermal growth factor receptor, designated 12-93. This antibody reacted with non-carbohydrate moiety of EGF-receptor (EGF-r) and inhibits the binding of EGF to its receptor. Using 12-93 IgG, expression of EGF-r in normal oral mucosa, normal salivary gland and oral cancer tumor tissues were determined by immunohistological studies.<BR>12-93 IgG staining appears largely restricted to basal cells on normal mucosa and ductal cells on normal salivary gland. On the other hand, cell membranes of all squamous cell carcinomas were uniformly stained but the intensity of staining was gradually decreased towards the center of cancer pearl.<BR>In salivary gland tumors, tumor cells especially exhibiting ductal formation were weakly but definitively stained with 12-93 IgG. These results strongly suggest the possibility that the expression of EGF-r may be involved in the malignant transformation of cells in oral salivary gland as well as oral mucosa. Furthermore, this antibody may be useful to study the expression of EGF-r in oral tumors.