Histamine H_2 拮抗剤の血中濃度に及ぼす併用薬の影響 (第3報) -Cimetidine と Sucralfate の同時および時差服用-

概要

論文の詳細を見る
Sucralfate (1.0g) was orally given each to five healthy males 2 hours after meal its effects on the blood concentration of oral cimetidine (200mg) was investigated. When sucralfate was given together with cimetidine, the blood concentration of cimetidine was decreased compared to that after postprandial administration of cimetidine alone, and the area under the plasma concentration curve (AUC0→∞) was significantly decreased (ca. 22%) as well, suggesting the inhibitory action of sucralfate against cimetidine absorption. However, when sucralfate was given 2 hours after postprandial cimetidine administration such effect of sucralfate was not observed at all. Therefore, in the combined oral therapy of cimetidine with sucralfate, it is theoretically desirable to separate administration of these drugs with an adequate doing interval.