IMMUNOFLUORESCENT STUDIES IN GASTRIC MUCOSA:IgA and Secretory Component

概要

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A study of local immunology of the gastric mucosa was carried out, with special reference to mucosal localization of secretory component (SC) and immunoglobulin A (IgA). The subjects were 9 cases of normal gastric mucosa, 15 cases of atrophic gastritis and 4 cases of regenerative epithelium around the gastric ulcer.The following results were obtained;1) A tendency was confirmed that SC was reactive in the foveolar epithelium more strongly in atrophic mucosa than the normal mucosa.2) IgA was hardly found in the foveolar epithelium of the normal gastric mucosa but found fairly strong in the foveolar epithelium of the atrophic mucosa.3) As to SC and IgA in relation with gland areas of pyloric gland, intermediate and fundic gland, both SC and IgA were reactive with the gland of atrophic mucosa in each gland area. The gland in normal gastric mucosa, however, SC and IgA were found not reactive.4) In the regenerative epithelium around gastric ulcer, both SC and IgA were observed strongly reactive.
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