Effects of concomitant drugs on the blood concentration of a histamine H2 antagonist. The 1st report. Oral administration of ranitidine together with high doses of neutralizing antacid and sucralfate.:Oral Administration of Ranitidine Together with High D

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High doses of neutralizing antacid (Maalox 60ml) or sucralfate (2.0g) was orally given each to five healthy males together with oral ranitidine (150mg) after fasting, and their effects on the blood concentration of ranitidine were investigated. The blood concentration of ranitidine was decreased either by Maalox or by sucralfate, compared to that after the administration of ranitidine alone. The area under the plasma concentration curve (AUC0→∞) was also decreased significantly: by 27% after ranitidine plus Maalox and 40% after ranitidine plus sucralfate, suggesting decrease in ranitidine absorption.When ranitidine is taken together with large amount of antacids (e.g. in cases of UGIT bleeding) or with sucralfate (e.g. in the usual treatment of peptic ulcer), the dosing schedule should be considered in order to avoid possible decrease in ranitidine absorption.