Effects of concomitant drugs on the blood concentration of a histamine H2 antagonist (The 2nd report) - Concomitant or time lag oral administration of ranitidine and sucralfate.:Concomitant or Time Lag Oral Administration of Ranitidine and Sucralfate

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Sucralfate (1.0g) was orally given each to five healthy males 2 hours after meal and its effects on the blood concentration of oral ranitidine (150mg) was investigated. When sucralfate was given together with ranitidine, the blood concentration of ranitidine was decreased compared to that after postprandial administration of ranitidine alone, and the area under the plasma concentration curve (AUC0→∞) was significantly decreased (ca. 22%) as well, suggesting the inhibitory action of sucralfate against ranitidine absorption. However, when sucralfate was given 2 hours after postprandial ranitidine administration, such effect of sucralfate was not observed at all. Therefore, in the combined oral therapy of ranitidine with sucralfate, it is theoretically desirable to separate the administration of these drugs with an adequate dosing interval.