Studies on the abnormalities of serum .ALPHA.1-acid glycoprotein in alcoholic patients.

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We investigated the quantitative and qualitative difference of serum α1-acid glycoprotein (α1-AG) derived from normal subjects and alcoholic patients. The serum zncentration of α1-AG of normal and alcoholics were 84.3±22.5mg/dl and 66.0±18.5 mg/dl, respectively. The values of alcoholics were significantly higher than that of normal subjects (p<0.01). The content of sialic acid of purified α1-AG from alcoholics was 0.12μg/mg protein and was 50% lower than that of normal subjects. This difference chiefly reflected the increase of asialo form of α1-AG in alcoholics, which was also confirmed by two dimensional isoelectric focusing-crossed immunoelectrophoresis. After two weeks of abstinense from alcohol, the serum asialo-α1-AG level tends to return to normal levels. Therefore, the quantitative and qualitative evaluation of α1-AG would be a useful marker for the biochemical assessment of alcohol intake.
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