悪性腫瘍に関連した creatine kinase の臨床病理学的検討-特に消化器癌について

概要

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It is well known that various enzymes of the human body increase and further more peculiar isoenzymes appear in the serum of the patients with malignant tumor.Creatine kinase isoenzymes (CK-BB) are one of the peculiar isoenzymes. Many papers have been reported on the appearance of CK-BB, cytoplasmic isoenzyme, in the serum of the patients with malignant tumor. Recently, mitochondrial CK (m-CK), which is different from cytoplasmic isoenzymes (CK-MM, CK-MB, and CK-BB) and existing in mitochondrial fraction, has been noticed because its possibility of the relation to malignant tumor. In this study, we evaluated m-CK in the serum of the patients with malignant tumor, particularly with the cancer of the gastrointestinal tract.Consequently, we found atypical CK isoenzyme in the serum of patients with malignant tumor, which is enzymatically very similar to m-CK (in the normal tissue). This atypical CK isoenzyme can be divided into at least two types according to the molecular weight. The appearance of this atypical CK suggested its specificity to the cancer.
財団法人日本消化器病学会の論文