原発性マクログロブリン血症の2症例

概要

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Macroglobulinemia of Waldenström is a disease of the reticuloendotherial system characterized by a marked increase in the serum gamma macroglobulin concentration.<BR>This syndrome bears some clinical resemblance to both multiple myeloma and chronic lymphatic leukemia and therefore has to be differentiated from these diseases especially the former.<BR>The differentiation from multiple myeloma is made by longer and more benign clinical course, the lack of osteolytic bone lesions and the infrequent finding of Bence Jones proteinemia.<BR>The next clinical chemical findings may be necessary to diagnose as Waldenström's macroglobulinemia : (1) characteristics of IgM in serum protein is monoclonal, (2) concentration of monoclonal IgM is greater than 1.0 g/dl in serum, and (3) monoclonal IgM fraction in serum is more than 15 per cent of total serum protein with ultracentrifugation.<BR>In this paper the results of clinical laboratory findings which examined 2 cases of Waldenström's macroglobulinemia in our hospital have been investigated and the criteria for the diagnosis of this disease have been reevaluated.
学校法人昭和大学・昭和医学会の論文