GLYCYLPROLINE DIPEPTIDYL AMINOPEPTIDASE ACTIVITIES IN SERUM AND LIVER OF RATS DURING 3'-METHYL DAB ADMINISTRATION

概要

論文の詳細を見る
Changes of glycylproline dipeptidyl aminopeptidase (GPDA) and r-glutamyl transpeptidase (γ-GTP) activities were compared in the serum and liver tissue of the rats with 3'-methyl DAB induced hepatoma. Subcellular distribution patterns of those enzymes were also studied in the process of carcinogenesis. Serum GPDA activity in rats with azodye-induced hepatoma was significantly higher than that in healthy rats, but serum GPDA activity was inclined to be elevated early after 3'-methyl DAB administration in comparison with the changes of γ-GTP. The specific activity of GPDA was decreased in the microsomal fraction and increased in the supernatant fraction of hepatic cancer tissue, suggesting that the enzyme is released from the microsomal fraction of the liver. Subcellular distribution pattern of GPDA was completely different from that of γ-GTP in hepatic cancer tissue.
財団法人日本消化器病学会の論文