Intra-arterial infusion and chemo-embolization therapy for hepatocellular carcinoma using lipiodol and cisplatin.

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We developed a new approach of intra-arterial infusion with chemoembolization for hepatocellular carcinoma (HCC) using lipiodol (LPD), cisplatin (CDDP) and gelfoam cube. The method is as follows: the mixture of LPD and CDDP was infused before and after the massive infusion of CDDP into the hepatic artery, fullowed by embolization by gelatin cube.From November 1984 to March 1986 we performed this therapy to 63 patients with HCC and 27 patients out of 63 received hepatic resection after this therapy.Therapeutic effect could be seen in all cases.In 36 cases without hepatic resection, one and two-year cumulative survival rate were 82.3% and 42.2%, respectively. These survival rate were statistically better than in cases treated by chemoembolization using.Adriamycin, LPD and gelfoam cube in which one- and two year cumulative survival rate were 50.0% and 30.0%, respectively. Better cumulative survival rate could be seen in group with 0 or 1 of performance status (p<0.01), male (p<0.05), serum AFP levels less than 400ng/ml (p<0.05) and without tumor invasion to portal vein. Side effect were not so severe and were transient in all cases.
財団法人日本消化器病学会の論文