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Relation of serum catecholamines and gastrin secretion was investigated in 6 patients with pheochromocytoma. Serum catecholamines were measured with a high performance liquidchromatography developed in our clinic.Results indicate that serum gastrin levels in the basal state and in response to a liquid test meal were significantly higher in patients with pheochromocytoma secreting adrenaline as well as noradrenaline, than in those with a tumor secreting noradrenaline alone. In patients with a tumor secreting adrenaline as well as noradrenaline, the surgical removal of a tumor resulted in a significant decrease in serum catecholamines and serum gastrin levels in the basal state and in response to a test meal.Experimental results of rats also indicate that adrenaline-stimulated gastrin secretion in the basal state and in response to a test meal was completely suppressed by propranolol, a betaadrenergic receptor blocking agent.It is concluded that beta-adrenergic mechanism are involved for the rise in serum gastrin in the basal state and in response to a test meal.
財団法人日本消化器病学会の論文