APPLICATION OF COIL PLANET CENTRIFUGE TO HEPATOBILIARY DISEASES

概要

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Osmotic fragility of erythrocytes in hepatobiliary diseases was examined using coil planet centrifuge system. Start point (HSP) and end point (HEP) of hemolysis correlated well and were shown to be deviated to hypoosmolar side especially in liver cirrhosis, liver cancer, and malignant biliary obstruction. The hemolysis patterns were divided into L, M, T, and R types and there was close correlation between hemolysis patterns and the degree of hepatic disturbances. In acute hepatitis hemolysis patterns took R type in its active stage and assumed L type in its convalescence. In chronic hepatitis or liver cirrhosis the hemolysis band was commonly of M or T type. The hemolysis band became R type with the right shift of HEP in liver cancer. In obstructive jaundice the hemolysis band became wider with a plateau at its peak (T type). Thus, the analysis of hemolysis patterns together with the shift of HEP was thought to be useful in the understanding and evaluation of the prognosis of hepatobiliary disorders.
財団法人日本消化器病学会の論文