OSMOTIC RESISTANCE OF ERYTHROCRTES IN OBSTRUCTIVE JAUNDICE:Part II. Changes of Lipid Composition of Erythrocyte Membrane in Obstructive Jaundice

概要

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Lipid composition of red cell membrane and its correlation with osmotic resistance were examined in obstructive jaundice. By using Iatroscan TH-10 TLC analyzer, lipids of red cell membrane were separated into free cholesterol (FC), phosphatidyl ethanolamine (PE), phosphatidyl serine (PS), phosphatidyl choline (PC) and sphyngomyelin (SM). FC: PE: PS: PC: SM ratio were 31.0: 20.1: 12.6: 19.5: 16.8 in normal controls. In benign biliary obstruction there were little changes compared with normal controls, while in malignant biliary obstruction FC: PE: PS: PC: SM were 39.1: 11.4: 8.4: 30.0: 11.0, which indicated increase of FC and PC and decrease of PE and SM. In addition, total lipids, FC/PL ratio and PC+SM/PE+PS ratio were significantly greater in malignant biliary obstruction.Hemolysis end point (HEP) correlated well with PE and SM (p<0.001) and a good correlation was also noted with FC, PC and total lipids (p<0.01). Lipid composition of erythrocyte membrane sharply reflects the changes of osmotic resistance of erythrocyte and seems to be useful in the diagnosis of obstructive jaundice.
財団法人日本消化器病学会の論文