電位差滴定による低過酸化物価測定法-5-高年齢者の過酸化脂質量について

概要

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We previously reported a potentiometric titration method which permits detection of very small amounts of hydroperoxides present in serum lipids. In the present work, lipid peroxide levels were determined by potentiometry in sera from about 400 subjects over 65 years old. The correlation of lipid peroxide levels with ageing was studied by comparing the levels of aged people with those of healthy young persons in their 20's or middle aged people in their 40's or 50's. <BR>The average serum lipid peroxide level of persons in their 40's was found to be 40.4±20.8 neq/mL, the highest of all male groups, decreased in proportion to the age of persons older than this. All female groups showed similar levels (<I>ca</I>. 26 neq/mL) independent of age. The specific values for the 40's group calculated as peroxide levels per 1 g of serum lipids exceeded those of other groups for both sexes, and were noted to decrease with ageing. <BR>Moreover, judging from the health conditions of subjects over 65 years old, the serum lipid peroxide levels of the cerebrovascular group appeared higher than those of the normal human group with significant difference. Since the subjects of typical geratic diseases surveyed in the present study were outpatients afflicted with mild forms of disease, further investigation should be conducted on patients of seriously afflicted to determine the correlation of serum lipid peroxide levels with various diseases.
日本油化学会の論文