マウス, ラットおよびコイにおける水銀化合物の代謝について : とくに全身および臓器別の生物学的半減期と体内分布からの検索

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Fish generally contain high levels of methylmercury, which may be due to the specific metabolism of mercury compounds. This paper attempts to clarify metabolic differences for mercury compounds in mice, rats and carp. Biological half-lives (BHL) throughout the body and in individual organs, and the distribution of mercury compounds injected intraperitonially were investigated by using radioactive mercury (203Hg). The following results were obtained.1. The disappearance patterns differed according to the animal species. Methylmercuric chloride disappeared rapidly and in a linear progression in mice. The BHL in mice was 7.8 days, and in rats also a relatively short 51 days, but the compound disappeared very slowly in carp with the BHL of 230 days in theory and more than 400 days in practice.2. There were low levels of mercuric chloride in tissues other than rat and carp kidneys, but there were high levels of methylmercuric chloride not only in the kidneys but in the blood, brain, liver, spleen, muscle and hair of all three animals. Accumulative distributions in carp muscle and excretive distributions in mouse and rat hair were found for methylmercuric chloride.3. The individual BHLs of mercuric chloride and methylmercuric chloride in rat liver, brain, spleen, blood, muscle and testicles were the same about 15 days, but differed from those in kidneys and hair, which had the same days as the BHLs in rat bodies. In animal bodies covered with hair as in the case of rats and mice, individual BHLs in hair affected the total BHL of methylmercuric chloride, a substance which is likely to be deposited in the hair.Differential metabolism of mercury compounds has been demonstrated in mice, rats and carp. Accumulative distributions of methylmercury in carp muscle in particular may cause the longer BHLs and support the high levels of methylmercury in fish.
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マウス, ラットおよびコイにおける水銀化合物の代謝について : とくに全身および臓器別の生物学的半減期と体内分布からの検索

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