ラットおよび魚類体内での無機水銀のメチル化について(Hg Series No.17)

概要

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The formation of methylmercury compounds from inorganic mercury in vivo was investigated in rats and fish.1. Chemical methylation of mercuric chloride mercurochrome with methylocbalamine, a vitamin B12 analog, was confirmed in vitro experiments.2. In rats exposed to inorganic mercury, methylmercury formation was not accelerated by the injection of methylcobalamine.3. A small quantity of methyl mercury compound was formed in rats administered inorganic mercury without methylcobalamine.The methylmercury content was particularly increased in the kidneys.4. In homogenates of whole fish, 203Hg-labeled methylmercury compound was found 10, 21 and 101 days after the injection of labeled mercuric chloride.5. No difference in degree of methylation was noted among various spesies of fish: catfish, carp and trout.Therefore the high level of methyl mercury in tuna and catfish in non-polluted water, as reported in the 2nd report, appeared to be unrelated to the high activity of biological methylation in vivo.
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